Based on the research theories and methods of evidence-based medicine, life science and food science, the Center, in collaboration with top universities at home and abroad, takes "How to Drink Healthily" as the guiding concept, and carries out work on alleviating alcoholic liver injury and evaluating nutritional and health functions from the overall, tissue, organ to cell and molecular levels.

1. Physiological Health Assessment Service

Based on the research of cell nutrition metabolism, functional food development, functional evaluation and in vivo action mechanism of natural active ingredients, and using the research methods and theories of life science and food science, this paper focuses on DNA damage repair (2015 Nobel Prize in Chemistry), cell autophagy (2016 Nobel Prize in Physiology), oxidative stress, inflammatory response, and apoptosis, follows the concept of evidence-based medicine, integrates a variety of animal models and disease models, and carries out health factor screening, health factor mining and its dose-effect synergy, acute drinking and health in the hepatocyte model, and long drinking and health in the animal model from the whole, tissue, organ to the cell molecular level.

2. Mental Health Assessment Service

Analyzing the mechanism of the antidepressant effect of alcohol on the human body from multiple perspectives such as behavior, pathology, and neuroscience, in order to address psychological health issues caused by alcohol. Analyze the degree of antidepressant effects of different types of alcohol one by one. The saying "drown sorrows with alcohol" has existed since ancient times. So, can drinking alcohol in clinical depression patients improve their mood? At least, from a biochemical perspective, it is possible. Our research findings suggest that alcohol and antidepressants share the same neural and molecular mechanisms of change.

1) High throughput screening and evaluation of overall wine samples, functional foods, and active ingredient biology;
2) Determine the functional factors of wine health and establish the direction of wine improvement;
3) Research on differences in wine samples and their biological mechanisms of action;
4) Development of new hangover biomarkers;
5) Technical support for cell biology and zoology;
6) Create health function products.

Articles (18 articles)

——Chen, S., Zhao, D., Luan, C., Zheng, J., Liu, W., Feng, Z., Luo, R., Han, X., & Wang, D.. Ferulic Acid Induces Autophagy and Apoptosis in Colon Cancer CT26 Cells via the MAPK Pathway. Molecules (Basel, Switzerland), 2023.

——Songbo G, Xinlin H, Shanbin C, et al. Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Signalling Pathway and Apoptosis Impact on the Effect of Tetramethylpyrazine against H2O2-Damage in Human Hepatic Cell Line (LO2 cells) [J]. American Journal of Biochemistry and Biotechnology, 2022.
——Li A, Chen S, Yang Z, et al. 4-Methylguaiacol alleviated alcoholic liver injury by increasing antioxidant capacity and enhancing autophagy through the Nrf2-Keap1 pathway[J]. Food Bioscience, 2022.
——Yishu Li, Heqiang Huang, Shengbao Feng, et al.The Alleviated Effect of α-Pinene on Amidst Alcoholic Liver Injury Pathology Through Autophagy Activation in Mice[J]. Journal of Nutrition and Food Processing.

——Zhao W, Fu Z, Wang X, et al. The effects of biogenic amines in Chinese Huangjiu on the behavior of mice and hangover headache‐related indices[J]. Food Science & Nutrition, 2022.

Patents (8)

-- A method to evaluate the influence of different trace components in wine body on the level of autophagy. Heqiang Huang ;Shanbin Chen ; Shanwen Li ; Xinglin Han ; Deliang Wang; Shengbao Feng ; Wenmei Zhao . CN116203002A
- A method to evaluate the degree of influence of trace component levels on cell health in wine.  WeiLu; Shanbin Chen; ZhenYang; Feck Hao;  Youhong Yang; Deliang Wang; Anjun Li; Xinglin Han . CN115521967A
-- A method for evaluating the degree of influence of trace component levels on alcohol metabolism. Fujie Huang ; Shanbin Chen ; Jun Lu;  Xinglin Han;  Deliang Wang. CN115109832A

Awards (7 items)

International leading achievements appraisal (13 items)

Cooperative enterprise

Cooperative university

Ruiqi Luo 18810991228